Clinical Summary
This 68-year-old man with a 7-year history of prostatic carcinoma developed metastases to the bones of the pelvis and lumbar spine which produced significant pain and discomfort. He was treated with androgen deprivation therapy to slow the growth of the tumor and decrease the size of the tumor metastases in order to help relieve his bone pain. The androgen deprivation therapy did reduce his pain; however, two months after starting the androgen deprivation therapy, the patient experienced an acute myocardial infarction and died suddenly.
Autopsy Findings
At autopsy the patient's myocardial infarction was found to have resulted from the thrombotic occlusion of the proximal left anterior descending coronary artery. There was evidence of cancer in the peripheral region of the prostate gland and there were metastases present in the pelvis and lumbar spine. The patient also had moderate testicular atrophy.
Images
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This is a low-power photomicrograph of a normal area from this patient's prostate. Note the corpora amylacea (arrow). |
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This high-power photomicrograph of the prostatic epithelium shows occasional cells with pyknotic fragmented nuclei (arrows). |
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Another high-power photomicrograph of the prostatic epithelium shows cells with pyknotic and fragmented nuclei (arrows). Note that the cytoplasm is condensed and hypereosinophilic. |
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Still another high-power photomicrograph of the prostatic epithelium demonstrates cells with pyknotic and fragmented nuclei (arrows). Again note the condensed and hypereosinophilic cytoplasm. |
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This photomicrograph of prostatic epithelium demonstrates an in situ immunohistochemical technique that is used to identify the DNA fragments characteristic of apoptotic nuclei. This technique, terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end-labeling (TUNEL) is used to identify apoptotic cells (arrows) in histology sections. |
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This is a higher-power photomicrograph of prostatic epithelium with the TUNEL staining. Note the apoptotic cells (brown nuclei) in the epithelium as well as those floating freely |