Smudge or basket cell
Smudge cells or basket cells are leukocytes that have been damaged during preparation of the peripheral blood smear. This usually occurs due to the fragility of the cell. They are usually seen in chronic lymphocytic leukemia (CLL).
Spherocytes
Spherocytes are red blood cells that are almost spherical in shape. They have no area of central pallor like a normal red blood cell. Large spherocytes (macrospherocytes) are seen in hemolytic anemia. Small spherocytes (microspherocytes) are sometimes seen in severe burn cases.
A variety of spherical forms are seen in hereditary spherocytosis. The cells depicted in this image are from a patient with hereditary spherocytosis.
Stomatocyte
Stomatocytes are red blood cells with an oval or rectangular area of central pallor, sometimes referred to as a "mouth". These cells have lost the indentation on one side and may be found in liver disease, electrolyte imbalance, and hereditary stomatocytosis.
Target cells
Target cells (codocytes) are erythrocytes with a central color spot in the area of pallor, resembling a target. They are seen in many hemolytic anemias, especially sickle cell, HbC disease, and thalassemia.
Teardrop cells (dacrocytes)
Teardrop shaped red blood cells are found in myelofibrosis and other myeloproliferative disorders, pernicious anemia, thalassemia, myeloid metaplasia, and some hemolytic anemias.
Toxic granulation
Toxic granulation appears as dark blue-black granules in the cytoplasm of neutrophils. These granules are thought to be primary granules.
Artifactual heavy granulation caused by poor staining is seen evenly spread throughout each cell and in all granulocytes, whereas toxic granulation is unevenly spread throughout the cytoplasm of certain cells. Large amounts of toxic granulation can give the neutrophil a bluish appearance.Toxic granulation is a stress response to acute infections, burns, and drug poisoning.
Yeast
The image below illustrates a neutrophil with intracellular yeast. The major function of the neutrophil is to stop or retard the action of foreign matter or infectious agents. The neutrophil accomplishes this by moving to the area of inflammation or infection, phagocytizing (ingesting) the foreign material (in this case, the yeast), and killing and digesting the material.
